The relation between serum vitamin D deficiency and allergic rhinosinusitis

Samer B. Kamel, Ahmed A. S. El‑Hamshary, Ahmed S. El‑Kady, Naslshah G. Kazem, Hafez A. M. Lamasha

Department of Otorhinolaryngology, Benha University, Benha, Egypt

It has been reported that the prevalence of allergic diseases, including asthma, food allergy, and allergic rhinitis (AR), is strongly associated with vitamin D deficiency. This study was conducted to evaluate the relation between vitamin D levels and AR in Egyptian patients.
Patients and methods
A total of 100 AR cases and 50 healthy controls were included. Cases were subjected to complete history taking and ENT examination. Vitamin D and immunoglobulin E levels were ordered for both cases and controls.
No significant difference was detected between cases and controls regarding demographics.
Regarding total nasal symptom score, it was mild in 44 cases, whereas 56 cases had moderate to severe scores. Serum vitamin D levels were significantly lower in cases compared with controls (16.9 vs. 28.3 ng/ml – P<0.001). Besides, vitamin D had lower levels in cases with higher total nasal symptom score. Conversely, immunoglobulin E was significantly higher in rhinitis cases compared with controls (1071.4 vs. 208.7 IU/ml – P<0.001). With a cutoff value of 13.6 ng/ml, lower vitamin D levels had sensitivity and specificity of 95.7 and 82.2%, respectively, to identify AR cases.
It is evident that low vitamin D levels are associated with AR. Moreover, the more deficiency detected in its levels, the more severe symptoms experienced by patients.
allergic rhinitis, immunoglobulin E, total nasal symptom score, vitamin D.

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